In this presentation, Alexandre Lemgruber will speak about the main achievements and challenges of the Health Technology Assessment Network of the Americas (RedETSA) and will delve into the role of the Pan American Health Organization (PAHO) in the institutionalization of Technology Assessment in Health (ETS) to improve decision-making processes in the region. Likewise, the results of the Advance HTA project for the region will be presented, including the regional mapping of the STD situation and decision-making.